Development of nanoemulsion based gel for the treatment of balanitis infection

Abstract

One of the most recent innovations in the Novel Drug Delivery System (NDDS) is nanoemulsion gel, which allows for the dual controlled release of an emulsion and a gel for topical application. When an emulsion is integrated into a gel, its stability is strengthened. It is challenging to conceptualize as a topical delivery. The goal of the current study was to create and improve the Clotrimazole nanoemulsion gel using different quantities of polymers such as Carbopol 934 and HPMC. The generated nanoemulsion gels were assessed for physical appearance, measurement of pH, viscosity, spreadability, drug content, and in vitro diffusion investigations as part of the Preformulation studies utilizing Fourier Transform Infrared (FTIR) research.Studies on the release of drugs in vitro were done for up to 8 hours. F6 exhibits better releasing property than any other formulations. F6was therefore shown to be the best formulation overall. When compared to formulations including Carbopol 934, F6 with low concentrations of HPMC polymer had greater releasing properties. Therefore, it was proposed that the Clotrimazole nanoemulsion gel might be superior to alternative topical drug delivery systems for integrating hydrophobic medicines and possessing improved activity and stability.