Association of Vitamin D Deficiency with Androgenetic Alopecia in a Male Population: A Case-Control Study

Abstract

Background: Androgenetic alopecia (AGA) is a hereditary condition characterized by progressive hair loss, often associated with androgens. While vitamin D is implicated in various hair disorders, its relationship with AGA, particularly in South Asian populations, is still debated.

Methods: This case-control study was conducted at a regional hospital in Solan and involved 20 male subjects: 10 with AGA and 10 age-matched controls. Serum vitamin D levels were measured, and participants underwent clinical evaluations. Statistical analysis included unpaired t-tests and chi-square tests.

Results: Vitamin D deficiency (<20 ng/ml) was more prevalent in AGA cases (60%) compared to controls (25%) (p=0.005), with an odds ratio of 4. Mean serum vitamin D levels were significantly lower in AGA cases (33.1±10.6 ng/ml) than in controls (40.3±9.51 ng/ml) (p=0.01). Severe AGA cases exhibited lower vitamin D levels compared to mild to moderate cases, though the difference was not statistically significant (p=0.32).

Conclusions: This study highlights the association between low vitamin D levels and AGA. Routine monitoring of vitamin D levels in AGA patients may be beneficial. Further research is needed to assess the therapeutic potential of vitamin D supplementation in AGA treatment.